杨坤

作者: 时间:2020-04-18

12361

杨  坤

职 务

生物工程教研室主任,硕士生导师

招生方向

制药工程,生物化工,生物工程

联系方式

Cell:18081078027

E-mail:cookyoung@scu.edu.cn

个人简介

具有超过十五年的生物工程相关领域的研究经验;研究兴趣广泛,涉及污水流行病学环境微生物及微生物生态生物分离、功能磁性微粒的制备及应用等多个领域;Science of the Total Environment,Frontiers in Microbiology,Applied and Environmental Microbiology,Chemical Engineering Science,mSphere, Separation and Purification TechnologyJournal Chromatography ABiochemical Engineering JournalIndustrial & Engineering Chemistry ResearchJournal of BiotechnologyAnalytical BiochemistryJournal of Applied Microbiology等国际知名的学术期刊上发表SCI论文近30篇,他引总次数超过500次。

教育经历

2002-092007-06, 天津大学, 化工学院, 博士;

1997-092001-06, 天津大学, 化工学院, 学士。

工作经历

2013.11至今, 四川大学, 化学工程学院, 副教授;

2008.05-2013.05, 夏威夷大学马诺阿分校, 博士后;

2007.09-2008.04, 厦门大学, 化学化工学院, 讲师。

研究领域

污水流行病学(for SARS-CoV-2)环境抗生素抗性功能磁性微粒及相关应用;环境微生物及微生物生态;生物分离。

新冠病毒(SARS-CoV-2)肆虐全球,全球疫情防控压力一直很大,针对个体的临床核酸检测耗费巨大的人力和物力。污水流行病学(Wastewater-Based Epidemiology, WBE)在市政污水管网特定位置布置采样点,采集污水样品进行病原体的生物学检测,可实现社区水平传染病近实时监测;WBE可以早于疫情爆发对病原体进行监测,对流行病的爆发做出提前预警;是临床疫情监测的有效补充,高效、低成本。

候鸟能介导环境抗生素抗性的远程传播,有时甚至是洲际传播抗生素耐药基因(Antibiotic Resistance Genes, ARGs)可移动基因元件(Mobile Genetic Elements, MGEs)的帮助下,可以在不同复制子之间(质粒之间或质粒和染色体之间),同种属的不同菌株之间,甚至不同种属的菌株之间水平转移(Horizontal gene transfer, HGT),其结构及运作机制类似于俄罗斯套娃。

科研项目

(1) 国家自然科学基金面上项目,22176133,基于宏基因组分析的抗生素抗性环境适应性研究,2022.01-2025.1260万元,在研,主持

(2) 国家自然科学基金面上项目,21677104,鸟类迁徙介导的环境抗生素抗性散播及内在机制研究,2017.01-2020.1268万元,结题,主持

(3) 四川大学引进人才科研启动经费资助项目,YJ201355,市政污水抗生素抗药性研究,2014.01-2016.1225万元,结题,主持

(4) Hawaii Department of Health11-093Survival of Fecal Indicator Bacteria and Waterborne Pathogens in Hawaiian Beach Sand2011.01-2012.1215万美元,结题,参加

(5) United States-Israel Binational Science Foundation2009276Molecular evolution of antibiotic resistance in soil exposed to anthropogenic factors2010.12 -2012.1112万美元,结题,参加

(6) National Institute of Food and Agriculture (U. S. A)N/AA new approach for bimolecular farming of high-value products in a contained environment, 2008.11-2011.07, 13万美元, 结题, 参加

(7) National Institute of Food and Agriculture (U. S. A)2005-55605-16683Development of an integrated rapid detection system for discrimination of Ralstonia Solanacearum strains in the environment2006.02-2010.0150万美元,结题,参加

(8) 国家自然科学基金面上项目,20476082,蛋白质离子交换吸附平衡的多尺度方法学研究,2005.01-2007.1223万元,结题,参加

(9) 国家自然科学基金青年科学基金项目,20306024,共聚焦激光扫描显微镜辅助多组分蛋白质吸附和色谱机理研究,2004.01-2006.1222万元,结题,参加。

发表文章

(1) Jinyong Wu, Zizheng Wang, Yufei Lin, Lihua Zhang, Jing Chen, Panyu Li, Wenbin Liu, Yabo Wang, Changhong Yao, Kun Yang*.Technical framework for wastewater-based epidemiology of SARS-CoV-2. Science of the Total Environment, 2021, 791: 148271.

(2) Jinyong Wu, Xiaohong Dong, Lihua Zhang, Yufei Lin, Kun Yang*.Reversing antibiotic resistance caused by mobile resistance genes of high fitness cost. mSphere, 2021, 6(3): e00356-21.

(3) Lihua Zhang, Kun Yang*Facilely Magnetized CuZnFe2O4-Activated Carbon Composite as an Efficient Recyclable Adsorbent of Cationic Dyes. Journal of Chemical and Engineering Data 2020, 65(11): 5532-5544.

(4) Yufei Lin, Xiaohong Dong, Rui Sun, Jiao Wu, Lejin Tian, Dawei Rao, Lihua Zhang, Kun Yang*. Migratory birds-one major source of environmental antibiotic resistance around Qinghai Lake, China. Science of the Total Environment, 2020, 739, 139758.

(5) Yufei Lin, Xiaohong Dong, Jiao Wu, Dawei Rao, Lihua Zhang, Yousef Faraj, Kun Yang*. Metadata Analysis of mcr-1-Bearing Plasmids Inspired by the Sequencing Evidence for Horizontal Transfer of Antibiotic Resistance Genes Between Polluted River and Wild Birds. Frontiers in Microbiology2020, 11: 352.

(6) Xiaohong Dong, Dawei Rao, Lejin Tian, Qizheng Wang, Kun Yang*A slurry microcosm study on the interaction between antibiotics and soil bacterial community. Heliyon, 2020, 6(2), e03348.

(7) Jiao Wu, Ye Huang, Dawei Rao, Yongkui Zhang, Kun Yang*. Evidence for Environmental Dissemination of Antibiotic Resistance Mediated by Wild Birds. Frontiers in Microbiology, 2018, 9: 745.

(8) Kun Yang*. Dynamic binary protein adsorption in ion-exchange media depicted with a parallel diffusion model derived from Maxwell-Stefan theory. Chemical Engineering Science, 2016, 139: 163-172.

教学工作

主讲本科生课程《生物环保与安全》、《代谢工程》、《生物信息技术》、《生物工程设计》等,承担《基因工程实验》;主讲研究生课程《微生物代谢调控》。

社会兼职

四川省饲料生产许可评审专家;

中国微生物学会会员;

四川大学党外知识分子联谊会会员;

Journal of Hazardous Materials等国际期刊审稿人。



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